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. 2017 Mar 20;7:44605. doi: 10.1038/srep44605

Table 4. Dynamically differentially expressed miRNAs throughout the bovine lactation curve.

miRNAs/Stages1 GAL_vs_LAC
INV_vs_LAC
INV_vs_GAL
Expression Pearson correlation with milk yield
L2FC3 p-value BH L2FC p-value BH L2FC p-value BH Pattern2 R p-value BH
bta-miR-106a −0.73 3.55E-07 −1.1 1.14E-09 −0.36 1.93E-02 D_D_D 0.073 0.567
bta-miR-148b −0.49 1.65E-02 −0.99 1.35E-04 −0.5 1.98E-02 D_D_D −0.034 0.792
bta-miR-EIA15-10681 −0.44 4.73E-02 −0.95 9.00E-04 −0.51 3.82E-02 D_D_D 0.105 0.408
bta-miR-EIA16-12736 −1.77 3.94E-07 −2.65 1.65E-08 −0.88 4.23E-02 D_D_D 0.206 0.102
bta-miR-183 −0.69 2.42E-02 −2.33 2.87E-10 −1.64 1.40E-07 D_D_D 0.245 0.051
bta-miR-19b −0.47 4.39E-03 −0.91 1.19E-05 −0.44 1.06E-02 D_D_D 0.106 0.406
bta-miR-EIA2-20521 −1.45 2.95E-06 −2.64 1.51E-10 −1.19 1.45E-03 D_D_D 0.102 0.424
bta-miR-224 −0.79 4.18E-03 −1.49 2.56E-05 −0.69 1.87E-02 D_D_D 0.004 0.975
bta-miR-2285t −1.43 1.99E-11 −2.65 7.18E-24 −1.22 9.32E-08 D_D_D 0.272 0.029
bta-miR-EIA26-29519 −0.49 6.48E-03 −0.89 1.29E-04 −0.4 4.62E-02 D_D_D 0.072 0.573
bta-miR-28 −0.75 6.08E-07 −1.32 8.72E-13 −0.57 3.35E-04 D_D_D 0.036 0.780
bta-miR-EIA4-36830 −0.92 1.19E-03 −2.56 1.32E-12 −1.64 2.29E-07 D_D_D 0.305 0.014
bta-miR-490 −2.38 3.52E-11 −4.03 1.90E-16 −1.65 3.30E-04 D_D_D 0.144 0.256
bta-miR-EIA6-40693 −2 1.90E-13 −3.16 8.56E-19 −1.16 4.02E-04 D_D_D 0.108 0.396
bta-miR-EIA8-45133 −1.98 8.62E-20 −2.68 4.53E-21 −0.7 8.00E-03 D_D_D 0.339 0.006
bta-miR-6524 −0.52 3.02E-02 −1.98 4.09E-12 −1.46 1.84E-09 D_D_D 0.124 0.330
bta-miR-7862 −0.82 1.20E-02 −1.79 3.43E-05 −0.97 9.37E-03 D_D_D 0.163 0.199
bta-miR-146b −2.15 7.61E-11 −1.33 2.44E-03 0.82 2.25E-02 D_U_D −0.160 0.207
bta-miR-582 −3.07 1.62E-10 −1.49 2.27E-02 1.58 2.68E-03 D_U_D −0.310 0.013
bta-miR-744 −1.6 5.23E-13 −0.8 7.54E-03 0.8 9.75E-04 D_U_D −0.290 0.020
bta-miR-10a −1.17 3.18E-02 1.6 2.70E-02 2.77 6.28E-07 D_U_U −0.310 0.013
bta-miR-149-5p −1.37 8.11E-06 1.01 1.45E-02 2.38 1.87E-13 D_U_U −0.292 0.019
bta-miR-EIA19-19133 −1.79 1.28E-02 2.24 5.27E-03 4.03 2.54E-09 D_U_U −0.399 0.001
bta-miR-221 −1.41 3.49E-03 2.05 8.97E-04 3.46 3.67E-12 D_U_U −0.439 <0.001
bta-miR-222 −1.58 1.06E-03 2.13 6.45E-04 3.71 1.87E-13 D_U_U −0.372 0.002
bta-miR-2323 −1.48 1.40E-02 1.47 4.84E-02 2.94 4.97E-07 D_U_U −0.406 0.001
bta-miR-2331-3p −1.47 1.37E-02 1.44 2.76E-02 2.91 1.34E-07 D_U_U −0.326 0.008
bta-miR-27a-3p −0.72 1.52E-02 1.28 6.45E-04 2 4.04E-11 D_U_U −0.343 0.006
bta-miR-27a-5p −0.75 3.83E-02 1.18 1.16E-02 1.93 1.19E-07 D_U_U −0.410 0.001
bta-miR-330 −1.66 6.96E-05 1.3 1.88E-02 2.96 8.71E-12 D_U_U −0.337 0.006
bta-miR-3432a −0.77 4.39E-03 1.04 2.70E-03 1.81 6.95E-11 D_U_U −0.446 <0.001
bta-miR-425-5p −0.6 1.37E-03 0.57 2.51E-02 1.17 1.76E-09 D_U_U −0.318 0.011
bta-miR-454 −1.12 7.65E-03 1.28 1.66E-02 2.4 9.96E-09 D_U_U −0.461 0.000
bta-miR-455-3p −1.62 4.31E-05 1.3 1.27E-02 2.92 1.49E-12 D_U_U −0.202 0.109
bta-miR-EIA5-37953 −0.76 4.69E-02 1.03 3.22E-02 1.79 1.77E-06 D_U_U −0.331 0.008
bta-miR-6529a −0.68 2.05E-02 1.21 9.51E-04 1.89 1.53E-10 D_U_U −0.466 <0.001
bta-miR-760-3p −0.63 1.53E-02 1 2.02E-03 1.63 3.77E-10 D_U_U −0.460 <0.001
bta-miR-877 −1.04 1.71E-04 0.86 1.87E-02 1.9 3.72E-11 D_U_U −0.314 0.011
bta-miR-152 0.51 3.83E-02 −0.65 4.84E-02 −1.15 3.67E-06 U_D_D 0.334 0.007
bta-miR-EIA19-17190 3.29 5.78E-16 2.08 7.04E-05 −1.21 2.57E-03 U_D_U 0.149 0.241
bta-miR-193a-3p 1.63 7.92E-10 0.96 6.21E-03 −0.67 1.35E-02 U_D_U 0.135 0.288
bta-miR-22-5p 1.11 4.67E-10 0.73 1.84E-03 −0.38 4.72E-02 U_D_U −0.038 0.764
bta-miR-2285o 1.8 5.77E-08 1.09 1.34E-02 −0.7 3.61E-02 U_D_U 0.168 0.184
bta-miR-29c 2.77 2.34E-26 2.1 4.13E-10 −0.68 1.89E-02 U_D_U 0.231 0.067
bta-miR-3064 2.63 1.26E-07 1.77 2.95E-03 −0.86 1.98E-02 U_D_U 0.121 0.340
bta-miR-30d 0.82 1.71E-07 0.43 4.64E-02 −0.38 2.25E-02 U_D_U 0.067 0.601
bta-miR-499 1.83 8.07E-12 1.11 1.62E-03 −0.72 9.65E-03 U_D_U 0.182 0.151
bta-miR-10b 2.71 3.06E-11 3.74 6.60E-14 1.03 1.44E-02 U_U_U −0.332 0.007
bta-miR-133a 1.37 1.13E-02 2.28 1.72E-04 0.91 3.65E-02 U_U_U −0.226 0.073
bta-miR-145 1.39 4.45E-04 2.65 6.01E-08 1.25 2.14E-03 U_U_U −0.310 0.013
bta-miR-154c 1.22 7.29E-03 2.3 1.41E-05 1.08 7.90E-03 U_U_U −0.181 0.151
bta-miR-EIA21-23041 2.31 2.70E-02 3.61 1.39E-03 1.3 4.81E-02 U_U_U −0.175 0.166
bta-miR-23a 0.36 2.55E-02 1.15 4.90E-09 0.79 2.11E-06 U_U_U −0.365 0.003
bta-miR-409a 1.38 1.41E-02 2.69 7.04E-05 1.31 1.35E-02 U_U_U −0.180 0.154
bta-miR-421 0.35 6.16E-03 0.69 1.19E-05 0.35 8.24E-03 U_U_U −0.257 0.040
bta-miR-493 1.34 1.29E-02 2.52 6.93E-05 1.19 1.38E-02 U_U_U −0.232 0.065
bta-miR-6120-3p 0.68 5.67E-06 1.06 1.26E-08 0.38 1.63E-02 U_U_U −0.373 0.002
bta-miR-9-3p 0.8 4.39E-02 1.93 3.51E-05 1.13 1.94E-03 U_U_U −0.336 0.007

1GAL- galactopoiesis, LAC- lactogenesis, INV- involution.

2D: down regulated, U: Up regulated.

3Log2fold change.