Table 4. Dynamically differentially expressed miRNAs throughout the bovine lactation curve.
miRNAs/Stages1 | GAL_vs_LAC |
INV_vs_LAC |
INV_vs_GAL |
Expression | Pearson correlation with milk yield |
||||
---|---|---|---|---|---|---|---|---|---|
L2FC3 | p-value BH | L2FC | p-value BH | L2FC | p-value BH | Pattern2 | R | p-value BH | |
bta-miR-106a | −0.73 | 3.55E-07 | −1.1 | 1.14E-09 | −0.36 | 1.93E-02 | D_D_D | 0.073 | 0.567 |
bta-miR-148b | −0.49 | 1.65E-02 | −0.99 | 1.35E-04 | −0.5 | 1.98E-02 | D_D_D | −0.034 | 0.792 |
bta-miR-EIA15-10681 | −0.44 | 4.73E-02 | −0.95 | 9.00E-04 | −0.51 | 3.82E-02 | D_D_D | 0.105 | 0.408 |
bta-miR-EIA16-12736 | −1.77 | 3.94E-07 | −2.65 | 1.65E-08 | −0.88 | 4.23E-02 | D_D_D | 0.206 | 0.102 |
bta-miR-183 | −0.69 | 2.42E-02 | −2.33 | 2.87E-10 | −1.64 | 1.40E-07 | D_D_D | 0.245 | 0.051 |
bta-miR-19b | −0.47 | 4.39E-03 | −0.91 | 1.19E-05 | −0.44 | 1.06E-02 | D_D_D | 0.106 | 0.406 |
bta-miR-EIA2-20521 | −1.45 | 2.95E-06 | −2.64 | 1.51E-10 | −1.19 | 1.45E-03 | D_D_D | 0.102 | 0.424 |
bta-miR-224 | −0.79 | 4.18E-03 | −1.49 | 2.56E-05 | −0.69 | 1.87E-02 | D_D_D | 0.004 | 0.975 |
bta-miR-2285t | −1.43 | 1.99E-11 | −2.65 | 7.18E-24 | −1.22 | 9.32E-08 | D_D_D | 0.272 | 0.029 |
bta-miR-EIA26-29519 | −0.49 | 6.48E-03 | −0.89 | 1.29E-04 | −0.4 | 4.62E-02 | D_D_D | 0.072 | 0.573 |
bta-miR-28 | −0.75 | 6.08E-07 | −1.32 | 8.72E-13 | −0.57 | 3.35E-04 | D_D_D | 0.036 | 0.780 |
bta-miR-EIA4-36830 | −0.92 | 1.19E-03 | −2.56 | 1.32E-12 | −1.64 | 2.29E-07 | D_D_D | 0.305 | 0.014 |
bta-miR-490 | −2.38 | 3.52E-11 | −4.03 | 1.90E-16 | −1.65 | 3.30E-04 | D_D_D | 0.144 | 0.256 |
bta-miR-EIA6-40693 | −2 | 1.90E-13 | −3.16 | 8.56E-19 | −1.16 | 4.02E-04 | D_D_D | 0.108 | 0.396 |
bta-miR-EIA8-45133 | −1.98 | 8.62E-20 | −2.68 | 4.53E-21 | −0.7 | 8.00E-03 | D_D_D | 0.339 | 0.006 |
bta-miR-6524 | −0.52 | 3.02E-02 | −1.98 | 4.09E-12 | −1.46 | 1.84E-09 | D_D_D | 0.124 | 0.330 |
bta-miR-7862 | −0.82 | 1.20E-02 | −1.79 | 3.43E-05 | −0.97 | 9.37E-03 | D_D_D | 0.163 | 0.199 |
bta-miR-146b | −2.15 | 7.61E-11 | −1.33 | 2.44E-03 | 0.82 | 2.25E-02 | D_U_D | −0.160 | 0.207 |
bta-miR-582 | −3.07 | 1.62E-10 | −1.49 | 2.27E-02 | 1.58 | 2.68E-03 | D_U_D | −0.310 | 0.013 |
bta-miR-744 | −1.6 | 5.23E-13 | −0.8 | 7.54E-03 | 0.8 | 9.75E-04 | D_U_D | −0.290 | 0.020 |
bta-miR-10a | −1.17 | 3.18E-02 | 1.6 | 2.70E-02 | 2.77 | 6.28E-07 | D_U_U | −0.310 | 0.013 |
bta-miR-149-5p | −1.37 | 8.11E-06 | 1.01 | 1.45E-02 | 2.38 | 1.87E-13 | D_U_U | −0.292 | 0.019 |
bta-miR-EIA19-19133 | −1.79 | 1.28E-02 | 2.24 | 5.27E-03 | 4.03 | 2.54E-09 | D_U_U | −0.399 | 0.001 |
bta-miR-221 | −1.41 | 3.49E-03 | 2.05 | 8.97E-04 | 3.46 | 3.67E-12 | D_U_U | −0.439 | <0.001 |
bta-miR-222 | −1.58 | 1.06E-03 | 2.13 | 6.45E-04 | 3.71 | 1.87E-13 | D_U_U | −0.372 | 0.002 |
bta-miR-2323 | −1.48 | 1.40E-02 | 1.47 | 4.84E-02 | 2.94 | 4.97E-07 | D_U_U | −0.406 | 0.001 |
bta-miR-2331-3p | −1.47 | 1.37E-02 | 1.44 | 2.76E-02 | 2.91 | 1.34E-07 | D_U_U | −0.326 | 0.008 |
bta-miR-27a-3p | −0.72 | 1.52E-02 | 1.28 | 6.45E-04 | 2 | 4.04E-11 | D_U_U | −0.343 | 0.006 |
bta-miR-27a-5p | −0.75 | 3.83E-02 | 1.18 | 1.16E-02 | 1.93 | 1.19E-07 | D_U_U | −0.410 | 0.001 |
bta-miR-330 | −1.66 | 6.96E-05 | 1.3 | 1.88E-02 | 2.96 | 8.71E-12 | D_U_U | −0.337 | 0.006 |
bta-miR-3432a | −0.77 | 4.39E-03 | 1.04 | 2.70E-03 | 1.81 | 6.95E-11 | D_U_U | −0.446 | <0.001 |
bta-miR-425-5p | −0.6 | 1.37E-03 | 0.57 | 2.51E-02 | 1.17 | 1.76E-09 | D_U_U | −0.318 | 0.011 |
bta-miR-454 | −1.12 | 7.65E-03 | 1.28 | 1.66E-02 | 2.4 | 9.96E-09 | D_U_U | −0.461 | 0.000 |
bta-miR-455-3p | −1.62 | 4.31E-05 | 1.3 | 1.27E-02 | 2.92 | 1.49E-12 | D_U_U | −0.202 | 0.109 |
bta-miR-EIA5-37953 | −0.76 | 4.69E-02 | 1.03 | 3.22E-02 | 1.79 | 1.77E-06 | D_U_U | −0.331 | 0.008 |
bta-miR-6529a | −0.68 | 2.05E-02 | 1.21 | 9.51E-04 | 1.89 | 1.53E-10 | D_U_U | −0.466 | <0.001 |
bta-miR-760-3p | −0.63 | 1.53E-02 | 1 | 2.02E-03 | 1.63 | 3.77E-10 | D_U_U | −0.460 | <0.001 |
bta-miR-877 | −1.04 | 1.71E-04 | 0.86 | 1.87E-02 | 1.9 | 3.72E-11 | D_U_U | −0.314 | 0.011 |
bta-miR-152 | 0.51 | 3.83E-02 | −0.65 | 4.84E-02 | −1.15 | 3.67E-06 | U_D_D | 0.334 | 0.007 |
bta-miR-EIA19-17190 | 3.29 | 5.78E-16 | 2.08 | 7.04E-05 | −1.21 | 2.57E-03 | U_D_U | 0.149 | 0.241 |
bta-miR-193a-3p | 1.63 | 7.92E-10 | 0.96 | 6.21E-03 | −0.67 | 1.35E-02 | U_D_U | 0.135 | 0.288 |
bta-miR-22-5p | 1.11 | 4.67E-10 | 0.73 | 1.84E-03 | −0.38 | 4.72E-02 | U_D_U | −0.038 | 0.764 |
bta-miR-2285o | 1.8 | 5.77E-08 | 1.09 | 1.34E-02 | −0.7 | 3.61E-02 | U_D_U | 0.168 | 0.184 |
bta-miR-29c | 2.77 | 2.34E-26 | 2.1 | 4.13E-10 | −0.68 | 1.89E-02 | U_D_U | 0.231 | 0.067 |
bta-miR-3064 | 2.63 | 1.26E-07 | 1.77 | 2.95E-03 | −0.86 | 1.98E-02 | U_D_U | 0.121 | 0.340 |
bta-miR-30d | 0.82 | 1.71E-07 | 0.43 | 4.64E-02 | −0.38 | 2.25E-02 | U_D_U | 0.067 | 0.601 |
bta-miR-499 | 1.83 | 8.07E-12 | 1.11 | 1.62E-03 | −0.72 | 9.65E-03 | U_D_U | 0.182 | 0.151 |
bta-miR-10b | 2.71 | 3.06E-11 | 3.74 | 6.60E-14 | 1.03 | 1.44E-02 | U_U_U | −0.332 | 0.007 |
bta-miR-133a | 1.37 | 1.13E-02 | 2.28 | 1.72E-04 | 0.91 | 3.65E-02 | U_U_U | −0.226 | 0.073 |
bta-miR-145 | 1.39 | 4.45E-04 | 2.65 | 6.01E-08 | 1.25 | 2.14E-03 | U_U_U | −0.310 | 0.013 |
bta-miR-154c | 1.22 | 7.29E-03 | 2.3 | 1.41E-05 | 1.08 | 7.90E-03 | U_U_U | −0.181 | 0.151 |
bta-miR-EIA21-23041 | 2.31 | 2.70E-02 | 3.61 | 1.39E-03 | 1.3 | 4.81E-02 | U_U_U | −0.175 | 0.166 |
bta-miR-23a | 0.36 | 2.55E-02 | 1.15 | 4.90E-09 | 0.79 | 2.11E-06 | U_U_U | −0.365 | 0.003 |
bta-miR-409a | 1.38 | 1.41E-02 | 2.69 | 7.04E-05 | 1.31 | 1.35E-02 | U_U_U | −0.180 | 0.154 |
bta-miR-421 | 0.35 | 6.16E-03 | 0.69 | 1.19E-05 | 0.35 | 8.24E-03 | U_U_U | −0.257 | 0.040 |
bta-miR-493 | 1.34 | 1.29E-02 | 2.52 | 6.93E-05 | 1.19 | 1.38E-02 | U_U_U | −0.232 | 0.065 |
bta-miR-6120-3p | 0.68 | 5.67E-06 | 1.06 | 1.26E-08 | 0.38 | 1.63E-02 | U_U_U | −0.373 | 0.002 |
bta-miR-9-3p | 0.8 | 4.39E-02 | 1.93 | 3.51E-05 | 1.13 | 1.94E-03 | U_U_U | −0.336 | 0.007 |
1GAL- galactopoiesis, LAC- lactogenesis, INV- involution.
2D: down regulated, U: Up regulated.
3Log2fold change.