Table 2.
Univariate and multivariate logistic regression analyses for predictors of the presence of prostate cancer at the second prostate biopsy.
| Univariate |
Multivariate |
|||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |||
| Age at initial PBx* | 1.04 | 1.009 | 1.070 | 0.010 | 1.06 | 1.021 | 1.101 | 0.003 |
| PSA at initial PBx* | 0.99 | 0.952 | 1.031 | 0.650 | ||||
| PSA at repeat PBx* | 1.01 | 0.984 | 1.037 | 0.450 | ||||
| Prostate volume* | 0.97 | 0.950 | 0.980 | < 0.001 | 0.97 | 0.950 | 0.985 | < 0.001 |
| No. of PBx core (≥13 vs. 12) | 1.83 | 1.096 | 3.044 | 0.021 | 2.56 | 1.332 | 4.926 | 0.005 |
| No. of PSA decrease at the first follow-up after initial PBx* | 1.51 | 0.817 | 2.778 | 0.189 | ||||
| Levels of PSA decrease at the first follow-up after initial PBx* | 1.01 | 0.958 | 1.063 | 0.741 | ||||
| PSAV before the initial PBx* | 0.99 | 0.952 | 1.031 | 0.650 | ||||
| PSAV before the repeat PBx* | 1.00 | 0.996 | 1.012 | 0.296 | ||||
| PSAV between the initial and repeat prostate biopsy* | 1.00 | 0.995 | 1.003 | 0.648 | ||||
| Average of PSA levels before the initial PBx* | 1.00 | 0.982 | 1.019 | 0.978 | ||||
| Standard deviation of PSA levels before the initial PBx* | 0.94 | 0.868 | 1.018 | 0.130 | ||||
| Average of PSA levels for the follow-up duration* | 0.94 | 0.853 | 1.038 | 0.225 | ||||
| Standard deviation of PSA levels for the follow-up duration* | 1.02 | 0.975 | 1.056 | 0.469 | ||||
| No. of PSA increase from the initial PBx before the repeat biopsy (≥ 4 vs. 0–3) | 1.87 | 1.008 | 3.460 | 0.047 | 1.33 | 0.665 | 2.654 | 0.421 |
| No. of PSA increase at the time from before the time for the follow-up duration (≥ 1 vs. 0) | 3.41 | 1.287 | 9.015 | 0.014 | 3.56 | 1.385 | 9.167 | 0.008 |
*, Continous variable.
CI, confidence interval; HR, hazard ration; PBx, prostate biopsy; PSA, prostate cancer-specific antigen; PSAV, PSA velocity.