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. 2017 Mar 20;8:97. doi: 10.3389/fneur.2017.00097

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Copyright © 2017 Hashim, Caverzasi, Papinutto, Lewis, Jing, Charles, Zhang, Lin, Graham, Schweizer, Bharatha and Cusimano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean diffusivity (MD) values are significantly higher in the traumatic brain injury (TBI) group with normal-appearing white matter. The MD contrast is overlaid on a standard Montreal Neurological Institute 152 T₁ 1 mm brain and the mean fractional anisotropy skeleton (green—display threshold 0.2–0.8). The voxels where MD was found to be significantly higher in the TBI group (p-value ≤ 0.05) are shown in red. Every fourth transverse slice only is shown here to approximately cover the entire brain along the superior–inferior axis. Anatomical right side of the brain is shown on the left in this figure.