Table 1.
AUC (±SD) (μM· hr) of Flavonoid Aglycones and Their Conjugates in Bile, Perfusate, Portal and Jugular Vein Following Intestinal Perfusion of Flavonoid Aglycones (10 μM).
| Intestinal Perfusion | Genistein | Biochanin A* | Apigenin | Chrysin | ||||
|---|---|---|---|---|---|---|---|---|
| Aglycone | Glucuronide | Aglycone | Glucuronide | Aglycone | Glucuronide | Aglycone | Glucuronide | |
| Bile | 4.0 | 28.8 | 0.096 | 21.0 | - | 9.4 | 1.0 | 2.4 |
| (0.23) | (9.3) | (0.061) | (2.8) | - | (3.1) | (0.26) | (0.91) | |
|
| ||||||||
| Perfusate | 2.4 | 3.2 | 1.6 | 12.4 | 1.4 | 4.8 | 3.3 | 0.87 |
| (0.70) | (0.83) | (0.42) | (1.8) | (0.70) | (1.1) | (1.3) | (0.46) | |
|
| ||||||||
| Portal | 0.37 | 0.010 | 0.010 | 0.019 | - | 0.0064 | 0.015 | 0.0078 |
| (0.17) | (0.0052) | (0.0082) | (0.0039) | - | (0.0024) | (0.019) | (0.0069) | |
|
| ||||||||
| Jugular | 0.40 | 0.0060 | 0.033 | 0.013 | - | 0.0010 | 0.0036 | - |
| (0.12) | (0.0047) | (0.042) | (0.0072) | - | (0.0012) | (0.0035) | - | |
*
Concentration at 150 min was not determined during experiments and hence AUC value for biochanin A was from 0 to 120 min. Interested reader may also find the actual amount of metabolite at different time points in Table S3 and S4 of Supplemental Information.