Table 1.
Characteristics of the GN and non-GN patients in the cohort. Data are presented as mean ± standard deviation (SD), median (IQR) or count (frequency)
| Variable | GN | Non-GN | P-value |
|---|---|---|---|
| Number | 288 | 1899 | |
| Median follow up (months) | 39.0 (33.5–39.0) | 39.0 (22.5–39.0) | |
| Age (years) | 58.9 ± 15.1 | 69.7 ± 11.7 | <0.001 |
| Male (%) | 189 (66%) | 1184 (62%) | 0.3 |
| Caucasian (%) | 241 (84%) | 1703 (90%) | <0.001 |
| Primary cause of kidney disease (%) | |||
| Diabetes | - | 777 (41%) | |
| Hypertension | - | 823 (48%) | |
| PCKD | - | 108 (6%) | |
| Other non-GN | - | 252 (13%) | |
| GN subtypes (%) | |||
| IgA Nephropathy | 61 (21%) | - | |
| FSGS | 35 (12%) | - | |
| ANCA Vasculitis | 21 (7%) | - | |
| Lupus Nephritis | 13 (5%) | - | |
| Membranous Nephritis | 9 (3%) | - | |
| GN Unspecified | 149 (52%) | - | |
| Diabetes (%) | 58 (20%) | 1025 (54%) | <0.001 |
| CVD history (%) | <0.001 | ||
| No CVD | 206 (72%) | 998 (53%) | |
| Ischemic HD | 33 (12%) | 365 (17%) | |
| CHF | 29 (10%) | 215 (11%) | |
| Ischemic and CHF | 20 (7%) | 321 (17%) | |
| Mean eGFR (ml/min/1.73 m2) ++/SD | 27.1 ± 9.1 | 27.7 ± 8.9 | 0.3 |
| eGFR categories (%) | 0.1 | ||
| < 20 ml/min | 81 (28%) | 428 (23%) | |
| 20–29 | 107 (37%) | 757 (40%) | |
| > 30 | 100 (35%) | 714 (40%) | |
| uACR (mg/mmol) | 59.5 [13.7–172.3] | 14.4 [2.9–76.8] | <0.001 |
| Systolic BP (mmHg) | 131 ± 18 | 134 ± 20 | <0.001 |
| Diastolic BP (mmHg) | 75 ± 12 | 70 ± 12 | <0.001 |
| Albumin (g/L) | 40.0 ± 4.8 | 40.4 ± 4.2 | 0.08 |
| Total cholesterol (mg/dL) | 4.6 ± 1.2 | 4.2 + 1.1 | 0.03 |
| Elevated Troponin I (% > LLD) | 71 (25%) | 714 (38%) | <0.001 |
| CRP (mg/mL) | 2.2 [0.9–5.3] | 3.0 [1.2–6.9] | <0.001 |
| ADMA | 0.54 ± 0.94 | 0.55 ± 0.12 | 0.1 |
| IL-6 (μg/L) | 3.04 [1.00–5.80] | 4.54 [1.00–7.25] | <0.001 |
| NT-ProBNP (pg/mL) Pg/mL | 273 [119–727] | 511 [213–1485] | <0.001 |
Abbreviations: PCKD polycystic kidney disease, FSGS focal segmental glomerulosclerosis, CVD cardiovascular disease, CHF congestive heart failure, BP blood pressure, LLD lower limit of detection, ADMA asymmetric dimethylarginine, IL-6 interleukin 6, NT-Pro-BNP N-terminal pro-brain natriuretic peptide