Table 3.
Characteristics of matched GN and non-GN groups. Results are presented as mean ± standard deviation, median (IQR) or count (frequency)
| Variable | GN | Non-GN | P value |
|---|---|---|---|
| Number | 272 | 272 | |
| Median follow up | 39.0 (33.2–39.0) | 39.0 (33.8–39.0) | |
| Age (years) | 60.5 ± 14 | 60.4 ± 14 | 0.9 |
| Male | 177 (65%) | 177 (65%) | 0.9 |
| Caucasian | 231 (85%) | 242 (89%) | 0.4 |
| Cause of Kidney Disease | |||
| Diabetic | - | 49 (18%) | |
| Hypertensive | - | 87 (32%) | |
| PCKD | - | 44 (16%) | |
| Other non-GN | - | 92 (34%) | |
| IgA | 60 (22%) | - | |
| FSGS | 33 (12%) | - | |
| ANCA Vasculitis | 21 (8%) | - | |
| Lupus | 13 (5%) | - | |
| Membranous Nephritis | 9 (3%) | ||
| GN unspecified | 136 (50%) | ||
| Diabetes | 57 (21%) | 60 (22%) | 0.7 |
| CVD history | 0.9 | ||
| No CVD | 193 (71%) | 201 (74%) | |
| Ischemic | 33 (12%) | 30 (11%) | |
| CHF | 27 (10%) | 25 (9%) | |
| Ischemic and CHF | 19 (7%) | 16 (6%) | |
| eGFR (ml/min/1.73 m2) | 27.0 ± 9.1 | 27.2 ± 9.1 | 0.8 |
| eGFR categories | 0.7 | ||
| < 20 | 76 (28%) | 68 (25%) | |
| 20–29 | 103 (38%) | 109 (40%) | |
| > 30 | 93 (34%) | 95 (35%) | |
| ACR (mg/mmol) | 58.7 [13.6, 170.2] | 17.2 [3.6–90.0] | <0.001 |
| Systolic BP (mmHg) | 132 ± 19 | 131 ± 19 | 0.8 |
| Diastolic BP (mmHg) | 75 ± 12 | 74 ± 12 | 0.4 |
| Statin | 158 (58%) | 147 (54%) | 0.3 |
| Albumin (g/L) | 39.8 ± 4.8 | 41.1 ± 4.2 | <0.001 |
| Total cholesterol (mg/dL) | 4.7 ± 1.2 | 4.5 ± 1.4 | 0.4 |
| Troponin I (> LLD) | 71 (26%) | 68 (25%) | 0.8 |
| CRP (mg/mL) | 2.4 [0.9–5.6] | 2.4 [1.1–5.5] | 0.6 |
| ADMA | 0.537 ± 0.094 | 0.534 ± 0.151 | 0.9 |
| IL-6 (μg/L) | 3.55 [1.00–6.02] | 3.5 [1.00–5.27] | 0.6 |
| NT-ProBNP (pg/mL) Pg/mL | 299 [121–799] | 291 [107–757] | 0.7 |
Abbreviations: PCKD polycystic kidney disease, FSGS focal segmental glomerulosclerosis, CVD cardiovascular disease, CHF congestive heart failure, BP blood pressure, LLD lower limit of detection, ADMA asymmetric dimethylarginine, IL-6 interleukin 6, NT-Pro-BNP N-terminal pro-brain natriuretic peptide