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. 2017 Mar 20;17:217. doi: 10.1186/s12879-017-2305-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — PHA767491 attenuates HSV-1 viral titers in animal model. RIP3 knockout mice were pretreated with DMSO or PHA767491 via intraperitoneal injection and infected with HSV-1 of 2× 107 pfus per mouse by intraperitoneal injection for 2 days. The viral titers in livers (a) and spleens (b) were determined by plaque assay. c The viral titers in the livers from RIP3 knockout mice were measured by immunohistochemistry. Arrows indicated the expression of viral protein gB. The results shown here are representative of seven mice (n = 7 per group)