Fig. 5.

Brain PET in Normal Rats: Sagittal sections (1.2 mm with respect to midline) through the rat brain from both [¹¹C]TAZA (injected with 90 MBq) and ¹¹C-Dalene (injected with 102 MBq). PET images are from baseline condition and frames were averaged >20–90 min. (B, E) Shows PET images associated with the MR template (A, D). The cross hair is positioned at 2.6 mm (A–P) and 5.7 mm (D–V) with respect to bregma. Time activity curves of [¹¹C]TAZA (C), and ¹¹C-Dalene (F) for brainstem (BS), frontal cortex (FC) and cerebellum (CB) regions are shown. [¹¹C]TAZA approached a plateau in the CB approximately 50 min postinjection while [¹¹C]Dalene approached a plateau in the CB approximately 40 min postinjection.