TABLE III.

In vivo pet measures of [¹¹C]radiotracers in rats

	Brain, %injected dose/cc						IBAT %Injected dose/cc
Radiotracer	Brain-stem	Brain-stem +ATX	Frontal Cortex	Frontal Cortex +ATX	Cerebellum	Cerebellum +ATX	Baseline	+ATX
[11C]TAZA
4.5 mina	0.013	0.990	0.007	0.627	0.010	0.695	0.015	0.148
85 minb	0.285	0.237	0.160	0.160	0.192	0.154	0.429	0.016
Ratioc	0.05	4.2	0.04	3.92	0.05	4.51	0.04	9.25
[11C]Dalene
4.5 mina	0.011	1.13	0.015	0.828	0.015	0.788	0.018	0.054
85 minb	0.124	0.534	0.069	0.304	0.072	0.304	0.118	0.050
Ratioc	0.09	2.12	0.22	2.72	0.21	2.59	0.15	1.08
[11C]PIB
4.5 mina	0.165	NA	0.714	NA	0.823	NA	0.165	NA
85 minb	0.056		0.045		0.124		0.056
Ratioc,d	2.95		15.9		6.64		2.95

^aInitial time of maximal uptake of radiotracers.

^bEnd of scan time.

^cRatio= uptake at 4.5 min/uptake at 85 min.

^dReported brain [¹¹C]PIB 2 min/30 min percent injected dose/g in mice ratio= 11 (Mathis et al., 2012). ATX= Atomoxetine; NA= Not available.