Fig. 1.

The effects of RIP3 knockout on in vivo hemostasis and thrombosis. (A) Tail bleeding time determined in groups of 36 WT and 36 RIP3^−/− mice. Horizontal lines indicated the median values. Statistical analysis was performed using the two-tailed Mann–Whitney test and revealed a significant difference between the two groups of animals. ***P < 0.001. (B) Representative images of FeCl₃-induced mesenteric arteriole thrombosis in WT and RIP3^−/− mice as recorded by real-time microscopy. Time after FeCl₃-induced injury is indicated at the bottom right of each image. (C) Occlusion time of the mesenteric arteriole as measured by FeCl₃ injury in WT and RIP3^−/− mice. Data are mean ± SEM values of 11 WT mice and 10 RIP3^−/− mice. **P = 0.0012.