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. 2017 Feb 28;114(11):E2243–E2252. doi: 10.1073/pnas.1614412114

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Fig. 4. — Global transcriptional profiling of iOL. (A) Hierarchical clustering of whole-genome expression profiles of iPSC (black), iPSC-derived NPC (green), iOL (28 d after transduction) (red), and human adult OL pOL (blue) revealed a strong correlation between iOL and pOL. (B and C) Pairwise scatterplot analysis of log₂-adjusted global gene-expression values of iPSC-derived NPC and their corresponding iOL (n = 10). Genes presenting with a <twofold difference in gene expression are illustrated in gray. (B) Characteristic OL-enriched genes were up-regulated in iOL, whereas (C) characteristic NPC-enriched genes were down-regulated.