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Gene ontology analysis performed for up- and down-regulated genes in iOL compared with iPSC-derived NPC
| GO term | Genes | P value |
| Up-regulated | ||
| Cell adhesion | 66 | 4.1E-12 |
| Regulation of action potential | 13 | 1.1E-6 |
| Lipoprotein | 41 | 1.3E-5 |
| Myelin sheath | 6 | 7.9E-5 |
| Axon ensheathment | 8 | 3.0E-4 |
| Ensheathment of neurons | 8 | 3.1E-4 |
| Myelination | 6 | 6.3E-3 |
| Down-regulated | ||
| DNA replication | 62 | 2.9E-32 |
| Nucleoplasm | 124 | 2.2E-27 |
| Cell cycle | 113 | 1.2E-25 |
| DNA repair | 60 | 1.6E-20 |
| Mitosis | 51 | 2.7E-19 |
