Fig. S5.

ClustalO sequence alignment of select IFIT sequences from humans, mice, and rabbits. Filled triangles indicate residues directly in contact with the RNA. Open triangles are positively charged residues lining the protein surface outside of the tunnel (in the groove). Secondary structure elements are indicated for human IFIT1 (colored by subdomain) and human IFIT5 (PDB ID code 4HOR). This figure was prepared using ESPript (espript.ibcp.fr/ESPript/ESPript/). National Center for Biotechnology Information reference numbers for mIfit1, mIfit1b, and mIfitc are NP_032357.2, NP_444447.1, and NP_001103987.1, respectively.