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Munc18-2 and the STX11/SNAP23/VAMP8 SNARE complex is required for CTL-mediated cytotoxicity. (A) Human CTLs were electroporated with either nontargeting (NT), Munc18-2, STX11, STX3, or VAMP8 siRNAs and cultured for 48 h. Cell lysates were analyzed by Western blot for the indicated proteins. (B) Plot showing the quantification of the knockdown efficiency of each protein compared with NT siRNA-treated cells as shown in A. Blots are representative of three independent experiments.
