Fig. 1.

Patterns of NER across the genome. (A) In untranscribed regions, damage in both strands is detected by UvrAB. XR-seq detects equal proportions of excised oligonucleotides from both strands. (B and C) In regions with simple transcription patterns (green arrows), greater excision of the TS is detected because UvrAB binds tightly to the Mfd/RNAP complex. Transcription levels affect the degree of strand bias. (D) Antisense transcription in some genes (orange arrow) can result in preferential repair of the annotated NTS.