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. 2017 Mar 23;2(6):e91738. doi: 10.1172/jci.insight.91738

Figure 9. Model Illustrating the PPARγ/RBP7/adiponectin transcriptional hub.

Figure 9

PPARγ is a nuclear transcription factor that induces expression of retinol-binding protein 7 (RBP7), an endothelium-specific PPARγ target gene. RBP7 facilitates transcriptional activation of RBP7-dependent PPARγ target genes including adiponectin (AdipoQ). Expression of these genes is impaired in the absence of RBP7. Expression of AdipoQ mediates an antioxidant response when the mice are challenged with either high-fat diet (HFD) or angiotensin II (Ang-II). Impairment of this protective response under conditions where either RBP7 or PPARγ is impaired causes oxidative stress and endothelial dysfunction in the presence of cardiovascular stressors.