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. 2017 Mar 23;2(6):e90196. doi: 10.1172/jci.insight.90196

Figure 5. Model of BCR and TLR4 pathways in ABC DLBCL.

Figure 5

A Schematic representation of the B cell receptor (BCR) and TLR pathways. Following BCR engagement, BTK coordinates the activation of IκB kinase (IKK) and leads to NF-κB signaling activation. Similarly, during signaling, MyD88 adaptor proteins stabilize and act as initial platform for IRAK4 recruitment and subsequently IRAK2 recruitment, resulting in NF-κB activation. The downstream activation of STAT3 triggers an autocrine loop, which automantains the MyD88 transcription.