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. 2017 Mar 23;2(6):e91863. doi: 10.1172/jci.insight.91863

Figure 5. CNS activation of STAT-3 phosphorylation (Tyr705) in the liver.

Figure 5

Results are expressed relative to liver from overnight-fasted control dogs in which insulin was basal (n = 2) compared to when insulin was elevated 6-fold by portal vein insulin infusion in the INS control (n = 5), brain insulin–block (INS-BRAIN, n = 9), and INS-COMPLETE (all of insulin’s indirect effects blocked, n = 5) groups. Values are means ± SEM. *STAT-3 phosphorylation in the INS-BRAIN and INS-COMPLETE groups was reduced (P < 0.05) compared with the INS group.