Fig. 2.

Onset of pain-related behaviour is delayed in Ccl2^−/−and Ccr2^−/−mice post DMM. 10 weeks old, male WT (C57Bl/6J), Ccl2^−/− and Ccr2^−/− mice underwent DMM or sham surgery. Pain-related behaviour was assessed twice weekly for the first week, then weekly by Linton Incapacitance testing. Statistical significance (ANOVA) was determined by comparing the difference between destabilised and sham-operated responses for Ccl2^−/− and Ccr2^−/− mice. Pain-related behaviour in WT mice is shown along side.