Table II.

Ratio of gene expression changes for the Ccl2^−/− or Ccr2^−/− mice over the changes in the WT mice at 6 h and 7 days post DMM. C_t values were normalised to the levels of RPS18

	6 h				7 Days
	Ccl2−/−/WT		Ccr2−/−/WT		Ccl2−/−/WT		Ccr2−/−/WT
	Ratio ± sd	P value	Ratio ± sd	P value	Ratio ± sd	P value	Ratio ± sd	P value
Adamts4	0.88 ± 0.17	ns	0.33 ± 0.07	0.015	0.76 ± 0.16	ns	0.26 ± 0.11	ns
Adamts5	1.98 ± 0.52	ns	0.89 ± 0.20	ns	1.44 ± 0.59	ns	0.73 ± 0.18	ns
Arg1	0.01 ± 0.01	<0.001	0.49 ± 0.09	0.022	0.75 ± 0.59	ns	3.08 ± 1.79	ns
Arg2	37.75 ± 10.50	0.0473	27.47 ± 6.33	0.028	40.99 ± 6.47	<0.001	4.98 ± 1.66	ns
Ccl2
Ccr2	0.76 ± 0.17	ns			0.44 ± 0.20	ns
Cd14	0.71 ± 0.31	ns	1.78 ± 0.54	ns	2.59 ± 1.38	ns	2.36 ± 1.13	ns
Cd68	0.49 ± 0.04	0.002	0.12 ± 0.04	<0.001	0.98 ± 0.43	ns	0.29 ± 0.09	ns
Has1	1.46 ± 0.19	ns	4.69 ± 0.67	0.001	16.34 ± 14.52	0.003	32.00 ± 28.34	<0.001
Has2	0.91 ± 0.23	ns	1.33 ± 0.48	ns	3.99 ± 1.15	0.025	0.89 ± 0.29	ns
Il1a	1.02 ± 0.12	ns	4.54 ± 1.22	ns	0.63 ± 0.11	ns	2.90 ± 0.98	ns
Il1b	0.71 ± 0.07	0.04	1.29 ± 0.28	ns	2.94 ± 0.99	ns	6.32 ± 1.27	<0.001
Il1r1	1.38 ± 0.75	ns	0.91 ± 0.58	ns	2.01 ± 0.38	ns	2.47 ± 0.68	ns
Il6	0.25 ± 0.06	0.03			1.46 ± 1.08	ns
Inhba	0.02 ± 0.01	<0.001	0.59 ± 0.10	0.028	0.75 ± 0.48	ns	1.52 ± 1.06	ns
Mmp13	1.74 ± 0.60	ns	1.60 ± 0.45	ns	4.05 ± 2.91	ns	1.23 ± 0.85	ns
Mmp3	0.36 ± 0.03	<0.001	0.20 ± 0.04	<0.001	17.84 ± 1.59	0.001	10.88 ± 1.49	0.006
Nos2	0.03 ± 0.01	0.027			0.09 ± 0.04	0.013
Ptges	0.53 ± 0.12	0.036	0.70 ± 0.15	ns	0.68 ± 0.25	ns	1.03 ± 0.36	ns
Ptgs2	0.06 ± 0.01	0.014	0.05 ± 0.01	0.012	0.05 ± 0.01	0.025	0.18 ± 0.05	0.037
Timp1	0.14 ± 0.05	0.003	0.86 ± 0.30	ns	1.16 ± 0.31	ns	2.91 ± 0.99	ns
Tsg6	1.07 ± 0.10	ns	1.71 ± 0.51	ns	1.02 ± 0.08	ns	0.25 ± 0.10	0.005