Table 2.

Initial differences and evolution over time of the neuropsychological tests according to the global thickness of the RNFL.

	Model A (n = 427)		Model B (n = 204)
	β (95% CI)	p	β (95% CI)	p
MMSE
RNFL	−0.006 (−0.020 to 0.007)	0.358	0.008 (−0.012 to 0.027)	0.434
RNFL × time	0.004 (−0.003 to 0.011)	0.234	0.002 (−0.007 to 0.011)	0.692
Isaacs’ set test at 30″
RNFL	−0.001 (−0.069 to 0.067)	0.986	0.004 (−0.090 to 0.098)	0.933
RNFL × time	0.001 (−0.020 to 0.023)	0.910	0.017 (−0.013 to 0.046)	0.264
FCSRT
Score of three free recallsa
RNFL	0.011 (−0.004 to 0.025)	0.153	0.015 (−0.005 to 0.036)	0.138
RNFL × time	0.001 (−0.004 to 0.007)	0.609	0.004 (−0.004 to 0.011)	0.342
Score of three free plus cued recallsb
RNFL	0.010 (−0.001 to 0.021)	0.089	0.013 (−0.003 to 0.029)	0.109
RNFL × time	−0.001 (−0.006 to 0.004)	0.662	−0.002 (−0.008 to 0.005)	0.589
Score of delayed free recallc
RNFL	−0.002 (−0.028 to 0.024)	0.862	−0.003 (−0.040 to 0.034)	0.869
RNFL × time	0.015 (0.005 to 0.025)	0.004	0.017 (0.003 to 0.030)	0.014
Score of delayed free plus cued recalls
RNFL	−0.006 (−0.017 to 0.004)	0.253	−0.010 (−0.024 to 0.005)	0.195
RNFL × time	0.007 (0.002 to 0.011)	0.004	0.011 (0.005 to 0.017)	<0.001

Model A adjusted for: time, age, interaction age/time, sex, school level, Apolipoprotein ε4, diabetes, diameter of optic nerve head, cataract surgery, and glaucoma.

Model B adjusted for: the same A-model with additional adjustment for axial length (AL) measure.

^aAdditional adjustment for the interaction sex/time in model A and B.

^bAdditional adjustment for the interaction diabetes/time in model A and B and the interaction AL/time in model B.

^cAdditional adjustment for the interaction Apolipoprotein ε4/time in model A and B.

MMSE, Mini–Mental State Examination; FCSRT, Free and Cued Selective Reminding Test; RNFL, retinal nerve fiber layer.

Bold p-value indicates p < 0.05.