Fig. 2.

The relationship between transepithelial conductance, G_T and the unidirectional absorptive oxalate flux, $J_{\mathrm{ms}}^{\mathrm{Ox}}$, across the distal colon from WT (filled circle) and DRA-KO (open circle) mice. Individual data points were collated from published studies [17, 45] together with the results from previously unpublished studies in our laboratory. $J_{\mathrm{ms}}^{\mathrm{Ox}}$ and G_T were measured on isolated segments of the distal colon mounted in the Ussing chamber under symmetrical, short-circuited conditions with standard bicarbonate buffer. Further methodological details are available in the supplementary material. The accompanying linear regression equation and analysis summary for WT mice is: $J_{\mathrm{ms}}^{\mathrm{Ox}}$ = 9.75 + (0.84 × G_T) (R² = 0.233) and F_1,83 = 25.15, P < 0.001. The regression equation and analysis summary for DRA-KO mice is: $J_{\mathrm{ms}}^{\mathrm{Ox}}$ = 0.97 + (1.49 × G_T) (R² = 0.378) and F_1,27 = 16.40, P < 0.001