Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr;137(4):845–854. doi: 10.1016/j.jid.2016.12.010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Similar epidermal defects in ARKID and Vps33b^fl/fl-ER^T2 mice. (a) Control and (b) ARKID palmar skin, H&E, scale bars = 1 mm. (c–e) ARKID skin TEM (c) LBs (*) and (d) lipid bilayers (arrows) within corneocytes, (e) inhomogeneous LB secretion (double arrows) and aberrant LBs, scale bars = 0.5 μm. (f, g) Dermoepidermal junction in (f) control and (g) ARKID abdominal skin, anchoring fibrils (arrows), scale bars = 0.5 μm. (h) wt and (i) Vps33b^fl/fl-ER^T2 dorsal epidermis, H&E, scale bars = 50 μm. (j) wt and (k) Vps33b^fl/fl-ER^T2 epidermis TEM: normal (white arrows) versus entombed bilayers (black arrows), aberrant LBs (*), scale bars = 0.2 μm. (l) aberrant LBs at the SG-SC interface (double arrows), scale bar = 2 μm. ARKID, autosomal recessive keratoderma-ichthyosis-deafness; BM, basement membrane; h, hemidesmosomes; H&E, hematoxylin and eosin; LB, lamellar body; SB, stratum basale; SC, stratum corneum; SG, stratum granulosum; SS, stratum spinosum; TEM, transmission electron microscopy; wt, wild type.