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. 2016 Dec 28;39(2):357–363. doi: 10.3892/ijmm.2016.2840

Figure 5.

Figure 5

Effect of miR-196a upregulation and Annexin A1 (ANXA1) overexpression on cell proliferation, migration and invasion. (A) The overexpression of miR-196a inhibited the expression of ANXA1, thereby inhibiting cell proliferation (p=0.027); co-transfection with ANXA1 expression plasmid reversed this inhibitory effect (p=0.034); (B) the overexpression of miR-196a inhibited cell migration (p=0.009); co-transfection with ANXA1 expression plasmid promoted cell migration (p=0.015); (C) the overexpression of miRNA-196a inhibited cell invasion (p=0.021); co-transfection with ANXA1 expression plasmid promoted cell invasion (p=0.045). Asterisks indicate significant differences with the indicated p-values.