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. 2016 Dec 29;39(2):307–316. doi: 10.3892/ijmm.2016.2843

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The effect of matrine on cell cycle progression was determined by propidium iodide (PI) staining and flow cytometry. Fibroblast-like synoviocytes (FLS) were isolated from control or collagen-induced arthritis (CIA) rats, cultured in vitro, and treated with 0.75 mg/ml matrine, 25 µmol/l AG490, or a combination of matrine and AG490 for 24 h. (A) Cell cycle distribution on FLS after 24 h of drug treatment. (B) Histogram depicts the percentage of cells in G0/G1, S and G2/M phases of the cell cycle. Data are expressed as mean ± SD of three independent experiments. ^*P<0.05, ^**P<0.01 vs. the control group; ^##P<0.01 vs. the CIA group; ^ΔP<0.05, ^ΔΔP<0.01 vs. the AG490 group.