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. 2016 Dec 29;39(2):307–316. doi: 10.3892/ijmm.2016.2843

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The effects of matrine on the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway were assessed by western blot analysis. Fibroblast-like synoviocytes (FLS) were isolated from control or collagen-induced arthritis (CIA) rats, cultured in vitro, and treated with 0.75 mg/ml matrine, 25 µmol/l AG490, or a combination of matrine and AG490 for 24 h. (A) Western blot analysis of p-JAK2, p-STAT1 and p-STAT3 levels. β-actin was used as a loading control. (B) Quantitative densitometry of p-JAK2, p-STAT1 and p-STAT3 levels relative to β-actin. Data are presented as mean ± SD of three independent experiments. ^**P<0.01 vs. the control group; ^#P<0.05, ^##P<0.01 vs. the CIA group; ^ΔP<0.05, ^ΔΔP<0.05 vs. the AG490 group.