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. 2016 Dec 29;39(2):307–316. doi: 10.3892/ijmm.2016.2843

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The therapeutic effects of matrine on collagen-induced arthritis (CIA) were assessed by arthritis index (AI) and ankle pathological analysis in control rats and CIA rats treated with 100 mg/kg matrine or 2 mg/kg methotrexate (MTX). (A) AI over 52 days of drug treatment (n=10 rats). Data are presented as mean ± SD. ^#P<0.05 vs. CIA group. (B–E) Representative H&E images of synovial tissues isolated from ankle joints. (B) Control animals exhibited smooth articular surfaces and no signs of inflammatory cell infiltration or cartilage destruction. (C) Rats with CIA displayed synovial hyperplasia, extensive inflammatory cell infiltration and cartilage destruction. (D) Rats in the CIA group treated with matrine exhibited slight synovial tissue hyperplasia, fewer immune infiltrates and no cartilage erosion or bone destruction. (E) Rats in the CIA group treated with MTX also displayed fewer immune infiltrates, and no signs of synovial hyperplasia or cartilage and bone destruction. All images were captured at ×200 magnification.