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. 2017 Jan 5;39(2):327–336. doi: 10.3892/ijmm.2017.2850

Figure 2.

Figure 2

The content and the peak area of neurotransmitters in the prefrontal cortex (n=6). (A) High performance liquid chromatography (HPLC) chromatogram of the standard substance in noradrenaline (NA) (1 µg/ml), adrenaline (Ad) (1 µg/ml), dopamine (DA) (2 µg/ml), tryptophan (Try) (1 µg/ml) and 5-hydroxytryptamine (5-HT) (1 µg/ml). The retention time of NA, Ad, DA, Try and 5-HT is ~7, 9, 18, 37 and 41 min, respectively. (B and C) HPLC chromatograms of neurotransmitters in the brain samples. The retention time of NA, Ad, DA, Try and 5-HT in the sample is the same as each standard substance. (D and E) Contents (ng/g) and peak area of each neurotransmitter in the sample. Summary data are expressed as the means ± SEM. As indicated, the content and the peak size of each neurotransmitter in the prefrontal cortex of depressed mice were lower than those of control group (P<0.05 or P<0.01); *P<0.05 or **P<0.01 compared with normal control group.