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. 2017 Jan 5;39(2):327–336. doi: 10.3892/ijmm.2017.2850

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Copyright: © Zhan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The expression of D site albumin promoter binding protein (DBP), γ-aminobutyric acid B receptor 2 (GABBR2) and SP proteins in the brain and spleen. Shown are representative western blots of proteins (upper panel) and summarized bar graphs (lower panel) (n=8, means ± SEM). (A and C) The expression levels of GABBR2 and SP proteins in the prefrontal cortex of the model group were significantly decreased compared to control group (P<0.01), while DBP expression significantly increased (P<0.01). Fluoxetine treatment significantly reversed the changes in DBP, GABBR2 and SP protein expression in the brains of mice in the depression model group (P<0.05 or P<0.01). (B and D) Similarly, the changes in the expression of DBP and SP proteins occurred in the spleen, which was coincident with the changes in the brain (P<0.01). Fluoxetine also reversed these changes. ^*P<0.05 or ^**P<0.01 depression model group compared with normal control group; ^#P<0.05 or ^##P<0.01 fluoxetine group compared with depression model group.