Table V.
The potential gene sequences in A. baumannii MDR-SHH02 relevant to antibiotic resistance.
| Gene ID | Resistance gene type from ARDB | Resistance gene class | Antibiotics |
|---|---|---|---|
| MDRSHH02002408 | aac(3)-Ia | Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation |
Astromicin, gentamicin, sisomicin |
| MDRSHH02000600 | aac(6′)-Ib | Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation |
Amikacin, dibekacin, isepamicin, netilmicin, sisomicin, tobramycin |
| MDRSHH02000597 | ant(2″)-Ia | Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation |
Dibekacin, gentamicin, kanamycin, sisomicin, tobramycin |
| MDRSHH02000611 | ant(3″)-Ia | Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation |
Spectinomycin, streptomycin |
| MDRSHH02001946 | aph33ib | Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation |
Streptomycin |
| MDRSHH02002406 | aph(3′)-Ia | Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation |
Gentamincin b, kanamycin, neomycin, paromomycin, lividomycin, ribostamycin |
| MDRSHH02001945 | aph(6)-Id | Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation |
streptomycin |
| MDRSHH02000608 | bl2b_tem, bl2b_tem1 | Class A β-lactamase. This enzyme breaks the β-lactam antibiotic ring open and deactivates the molecule's antibacterial properties | Cephalosporin, penicillin, cephalosporin i, cephalosporin ii |
| MDRSHH02000599 | catb3 | Group B chloramphenicol, acetyltransferase which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase | Chloramphenicol |
| MDRSHH02000610 | sul1 | Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide | Sulfonamide |
| MDRSHH02001738 | sul2 | Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide | Sulfonamide |
| MDRSHH02001941 | tetb | Major facilitator superfamily transporter, tetracycline efflux pump | Tetracycline |
A. baumannii, Acinetobacter baumannii; ARDB, Antibiotic Resistance Genes Database; DDA, disc diffusion assay. The antibiotics in bold are resisted by A. baumanii MDR-SHH02 in the DDA.