Table 4. Antiprotozoal activity of temporin-SHa and [K3]temporin-SHa.
| IC50 (μM) | ||
|---|---|---|
| SHa | [K3]SHa | |
| Leishmania promastigotes | ||
| L. infantuma | 18 (8)b | 10 (5)b |
| L. infantum (antimony resistant) | 14 | 9 |
| L. major | 13 | 10 |
| L. braziliensis | 7 | 5 |
| L. amazonensis | 13 | 8 |
| Leishmania amastigotes | ||
| L. infantum (axenic) | 20 | 20 |
| L. infantum (intramacrophagic) | 9 | 5 |
| Trypanosoma epimastigotes | ||
| T. brucei gambiense | 14 | 16 |
| T. cruzi | 17 | 10 |
a [A2,6,9]SHa and [A2,6,9, K3]SHa were inactive against L. infantum promastigotes (IC50 > 200 μM).
b values in parentheses were obtained in serum-free medium.