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. 2017 Mar 7;7:43846. doi: 10.1038/srep43846

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Copyright © 2017, The Author(s)

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Cell viability was evaluated by MTT reduction. DIV14 NMNAT2 WT, HET, or KO neurons were pretreated with DMSO or 10 uM of the indicated compounds for 6 hours and then exposed to either DMSO (blue) or drug + vincristine (magenta) for additional 6 hours. Statistical significance within each group was assessed by two-tailed T-test, and intergroup differences were assessed by one-way ANOVA. *Compared to DMSO only; ^#compared to DMSO + vincristine; ^$compared to drug + DMSO. ^*/#/$p < 0.05, ^**/##/$$p < 0.001 ^***/###/$$$p < 0.0001.