Table 3. Independent predictors of new-onset acute myocardial infarction in patients with gastroesophageal reflux disease under proton pump inhibitors use.

Variable	Crude HR (95% CI)	P-value	Adjusted HR (95% CI)	P-value
PPIs
Non-GERD(n = 269,572) vs GERD without PPI(n = 38,067)	0.71(0.62, 0.81)	<0.001*	0.69(0.60, 0.80)	<0.001*
GERD with PPI>1 year(n = 1,345) vs GERD without PPI(n = 38,067)	0.88(0.48, 1.61)	0.675	0.57(0.31, 1.04)	0.066

CI, confidence interval; HR, hazard ratio; PPIs, proton pump inhibitors.

Adjusted for age, sex, hypertension, diabetes mellitus, hyperlipidemia, congestive heart failure, and ischemic stroke.

*P-value < 0.05 was considered statistically significant after test.