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(a) Schematic representation of multiple conformational substates of p53TAD that interact with a SNP with differential binding propensities determined by the primary sequence. The lengths of the arrows reflect variable kon for different p53TAD regions. (b) Long-range effect of positively charged Lys24 on the association rate constant kon of p53TAD with anionic SNP as a function of residue position along the primary sequence.
