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. Author manuscript; available in PMC: 2018 Mar 17.
Published in final edited form as: Circ Res. 2017 Mar 17;120(6):941–959. doi: 10.1161/CIRCRESAHA.116.309040

Figure 4. Model of cardiomyocyte regeneration.

Figure 4

During heart regeneration, myocardial injury and CM loss induce the dedifferentiation of a fraction of CMs (pink). These CMs reenter the cell cycle, produce new CMs, and replenish the lost CMs. CMs that are generated from cell division re-differentiate to a fully mature state to improve heart contraction.