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. 2017 Mar 20;12(3):e0173914. doi: 10.1371/journal.pone.0173914

Fig 2. Hepatic ammonia staining in mouse models and human samples of acute and chronic liver injury.

Fig 2

Representative micrographs of H&E and ammonia staining in liver samples in bile-duct ligation (BDL) mouse model of liver injury (n = 6 Ctrl, n = 6 BDL 10 days and, n = 4 BDL 14 days, *p<0.05 vs. Ctrl) (A), in the transgenic mouse model of cholestatic disease, the Mdr2-/- mouse (n = 6 Mdr2+/+ and n = 6 Mdr2-/-, *p<0.05) (B) and, in acetaminophen-induced liver injury in mouse (n = 6 Ctrl, n = 8 Acetaminophen, *p<0.05) (C). Serum ammonia both in BDL and in the Mdr2 mouse models are shown, *p<0.05 is indicated (D). Finally, representative micrographs of H&E and ammonia staining in the liver of cirrhotic patients (n = 6 healthy and n = 6 Cirrhosis, *p<0.05) (E) and in idiosyncratic drug-induced liver injury (DILI) patients (n = 5 healthy, n = 5 DILI and n = 3 Acute DILI, *p<0.05 Acute DILI vs. healthy) (F) are shown.