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. 2017 Mar 6;13(3):e1005413. doi: 10.1371/journal.pcbi.1005413

Fig 7. Common reactions in ensemble are consistent with manually-curated reconstruction.

Fig 7

A. We generated an ensemble of 100 GENREs using a randomly-selected 80% of the reactions in iPAU1129, and then sequentially gap filled from the universal reaction database using 25 randomly-selected positive growth conditions. B. The distribution of reactions throughout the ensemble is displayed as the proportion of reactions (y-axis) which are found in a given number of GENREs (x-axis). “Correct” reactions are those which are found in the manually-curated iPAU1129, while “incorrect” reactions are those which are added during gap filling but not found in iPAU1129. We observed that there is a common set of reactions which were found in all 100 GENREs. The majority of this common set are “correct” (88 reactions) while 23 are “incorrect”. C. The common reactions (found in 50 or more GENREs) consist of a greater proportion of “correct” reactions. “Incorrect” reactions tend to be uncommon.