Table 1.

Reported cases of bullous pemphigoid developing in close association with melanoma without the use of melanoma immunotherapy

Marks [1]	61-year-old woman	Four-month history of oral blistering with new-onset development of cutaneous blisters. At the 1-month follow-up, the patient noted a nevus that had been bleeding intermittently over the course of a year. Following excision of melanoma, the patient’s skin lesions, but not oral lesions, resolved without treatment. A significant flare of bullous pemphigoid occurred several months later and she was noted to have an enlarged lymph node containing melanoma. Following removal of the involved node, the patient was able to be controlled on 2.5–5 mg of prednisone per day compared with the 60 mg required before lymph node resection
Parsons and Savin [2]	57-year-old woman	Five months following the diagnosis of bullous pemphigoid, the patient had a melanoma excised from her back. Four years later, the patient had an acute flare of bullous pemphigoid and was noted to have newly discovered metastatic deposits on chest radiograph as well as lymph node invasion
Parimi et al. [3]	74-year-old man	The patient presented with a new-onset severe bullous pemphigoid, requiring hospitalization. One month following hospitalization, the patient was noted to have darkening of the right toe nail bed. Biopsy indicated melanoma, with a chest radiograph showing lung metastases and lymphadenopathy
Beck et al. [4]	72-year-old man	The patient with a previous history of melanoma was found to have recurrent subungual melanoma with positive sentinel nodes. Within 1 year of this recurrence, the patient developed bullous pemphigoid, followed by discovery of distant metastases. Exacerbated with ipilimumab and pembrolizumab treatment
This case	88-year-old woman	An 88-year-old woman initially presented for evaluation of a pruritic rash. At this time, the patient noted a 4-month history of a growing pigmented vulvar lesion, found to be melanoma. Following excision of the melanoma, the patient was able to be managed on doxycycline and niacinamide without flares