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. 2017 Mar 19;19(4):364–373. doi: 10.1016/j.neo.2017.02.009

Figure 5.

Figure 5

The effect of BCNU alone and BCNU + RTV on tumor growth in vivo. Mice were inoculated with GL261 cells and imaged after 10 days just before the start of treatment, and 14 days later. The images are divided into three groups according to treatments: control (CTRL), BCNU (BCNU 1.5 mg/kg alone), BCNU (same as before). and RTV (100 mg/kg). In each group, the first row (pretreatment) shows the results of MRIs performed on day 10 after tumor inoculation, whereas the second row (post treatment) shows images obtained 14 days after the start of treatment (24 days after the inoculum). For each animal, in the first column, T2-weighted images are reported, whereas in the second column, T1-weighted images after gadolinium injection are displayed. The stippled lines present in T2-weighted images delimit the area of the tumor, whereas the tumor is indicated by an arrow in the corresponding T1-weighted images.