Table 1.

Combination Index Analysis

BCNU (μM)	RTV (μM)	BCNU	RTV		CI
		IC50EQ	IC50EQ	Ratio	CI = (d1/50) + (d2/45)
50	0	1.0000	0.0000
40	1	0.8000	0.0227	1:0.03	0.82	Synergy
20	13	0.4000	0.2955	1:0.7	0.70	Synergy
10	22	0.2000	0.5000	1:2.5	0.70	Synergy
5	30	0.1000	0.6818	1:6.8	0.88	Synergy
0	45	0.0000	1.0000

TMZ (μM)	RTV (μM)	TMZ	RTV		CI
		IC50EQ	IC50EQ	Ratio	CI = (d1/400) + (d2/45)
400	0	1.0000	0.0000
300	1	0.7500	0.0227	1:0.003	0.77	Synergy
200	10	0.5000	0.2273	1:0.05	0.73	Synergy
100	20	0.2500	0.4545	1:0.2	0.70	Synergy
50	25	0.1250	0.5682	1:0.5	0.69	Synergy
10	30	0.0250	0.6818	1:3	0.71	Synergy
0	45	0.0000	1.0000

BCNU (μM)	IDV (μM)	BCNU	IDV		CI
		IC50EQ	IC50EQ	Ratio	CI = (d1/50) + (d2/500)
50	0	1.0000	0.0000
40	50	0.8000	0.1100	1:1.25	0.91	Synergy
40	100	0.8000	0.2200	1:2.50	1.02	Additivity
30	200	0.6000	0.4400	1:6.67	1.04	Additivity
30	300	0.6000	0.6600	1:10	1.26	Antagonism
20	300	0.4000	0.6600	1:15	1.06	Additivity
0	500	0.0000	1.0000