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. 2017 Feb 23;13(2):e1006214. doi: 10.1371/journal.ppat.1006214

Fig 10. Differential fitness impact of the substitution L665W on prototype isolates of HCV genotypes 1–6.

Fig 10

Mutations encoding L665W was introduced into cell-cultures adapted HCV Core-NS2 recombinants with or without HVR1 of genotypes (A) 2a (J6/JFH1), (B) 3a (S52/JFH1), (C) 4a (ED43/JFH1), (D) 5a (SA13/JFH1) and (E) 6a (HK6a/JFH1). Huh7.5 cells were transfected with in vitro transcribed RNA of the indicated recombinants. Supernatants were collected at the indicated time-point and HCV infectivity titers were determined as indicated in Materials and Methods.