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. 2017 Feb 23;13(2):e1006214. doi: 10.1371/journal.ppat.1006214

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© 2017 Velázquez-Moctezuma et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 11 — 1st passage virus stocks of the indicated viruses were subjected to a dilution series of AR5A and the IC₅₀ was determined for virus with (A) and without HVR1 (B). Numbers represent the number of times that the IC₅₀ of a HCV virus with L665W is higher than its parental virus. J6/JFH1_L665W harbored the substitution I262L, S52/JFH1_L665W harbored the substitution I355F and S52/JFH1_ΔHVR1/L665W harbored the substitutions A372V, Q454H/q and F580V. *IC₅₀ could not be determined as less than 50% neutralization was observed at the highest tested AR5A concentration.