Table 2.
Main characteristics of the whole population of COPD patients (having complete SGRQ data; n=73) and of its better-controlled (n=37) and worse-controlled (n=36) groups
| Parameters | Whole population | Better-controlled | Worse-controlled | P-value |
|---|---|---|---|---|
| Demographic and anthropometric parameters | ||||
| Age (years) | 62.01±9.70 | 61.32±8.35 | 62.72±10.99 | 0.542 |
| Gender (female/male) | 27/46 | 13/24 | 14/22 | 0.740 |
| Height (m) | 1.68±0.09 | 1.70±0.10 | 1.66±0.08 | 0.083 |
| Weight (kg) | 79.61±17.22 | 82.36±18.65 | 76.77±15.37 | 0.173 |
| Lung function test parameters | ||||
| FVC% pred | 82.30±17.44 | 87.46±16.58 | 77.00±16.90 | 0.009 |
| IVC% pred | 87.00 (74.00–100.00) | 89.00 (78.00–100.00) | 85.00 (70.00–99.50) | 0.166 |
| TLC% pred | 113.00 (103.00–127.00) | 108.00 (101.00–120.00) | 121.50 (106.50–130.00) | 0.086 |
| TGV% pred | 140.00 (123.00–167.00) | 135.00 (116.00–155.00) | 157.00 (126.50–178.50) | 0.025 |
| RV% pred | 172.03±47.23 | 157.14±35.80 | 187.33±52.87 | 0.006 |
| RV/TLC% pred | 140.47±20.99 | 132.00±16.71 | 149.17±21.57 | <0.001 |
| FEV1% pred | 66.08±20.04 | 74.19±16.98 | 57.75±19.71 | <0.001 |
| PEF% pred | 52.00 (39.00–73.00) | 58.00 (50.00–77.00) | 41.50 (29.50–59.50) | <0.001 |
| FEF25–75%% pred | 35.00 (24.00–53.00) | 42.00 (29.00–60.00) | 28.50 (18.50–46.50) | 0.006 |
| MEF50%% pred | 37.00 (20.00–58.00) | 43.00 (32.00–63.00) | 24.50 (16.00–49.00) | <0.001 |
| FEV1/IVC% pred | 76.11±16.36 | 82.19±13.36 | 69.86±16.96 | <0.001 |
| FEV1/FVC | 0.65 (0.54–0.74) | 0.68 (0.64–0.76) | 0.59 (0.48–0.71) | 0.007 |
| Raw (kPa⋅s/L) | 0.27 (0.22–0.42) | 0.25 (0.20–0.31) | 0.33 (0.26–0.53) | 0.008 |
| Gaw (L/kPa⋅s) | 3.67 (2.36–4.64) | 3.96 (3.27–4.96) | 3.07 (1.90–3.86) | 0.007 |
| SGRQ | ||||
| Symptoms score | 32.66 (13.64–58.28) | 13.64 (5.20–25.55) | 60.02 (43.24–76.70) | <0.001 |
| Impacts score | 29.66 (17.09–49.79) | 18.51 (10.10–29.66) | 47.01 (31.34–54.40) | <0.001 |
| Activity score | 59.45 (47.63–72.08) | 52.14 (24.62–59.45) | 66.41 (57.32–82.57) | <0.001 |
| Total score | 41.08±20.99 | 27.61±15.94 | 54.93±15.98 | <0.001 |
Notes: Patients in the better-controlled group had a Symptoms score smaller than the median Symptoms score (for the whole cohort), while Symptoms score of patients in the worse-controlled group reached or exceeded this median value (32.66 was the median SGRQ Symptoms score of the whole cohort). Data are presented as mean ± SD or median (interquartile range) unless otherwise stated. Differences between the two groups were considered significant at P<0.05 (indicated in bold). Clinically meaningful differences of SGRQ results are underlined. It should be noted that only 73 patients had complete SGRQ results.
Abbreviations: SGRQ, St George’s Respiratory Questionnaire; FVC, forced vital capacity; IVC, inspiratory vital capacity; TLC, total lung capacity; TGV, thoracic gas volume; RV, residual volume; FEV1, forced expiratory volume in 1 s; PEF, peak expiratory flow; FEF25–75%, forced expiratory flow between 25% and 75% of FVC; MEF, maximal expiratory flow; Raw, airway resistance; Gaw, airway conductance; SD, standard deviation.