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Schematic representation of the hypoxia regulation pathway.
Abbreviations: 2-OG, 2-oxoglutarate; 2-HG, 2-hydroxyglutarate; 2-OGDDs, 2-oxoglutarate-dependent dioxygenases; IDH, isocitrate dehydrogenase; FH, fumarate hydratase; SDH, succinate dehydrogenase; PHD, prolyl hydroxylase domain protein; VHL, von Hippel–Lindau; HIF, hypoxia inducible factor; alt.splicing, alternative splicing; SOD, superoxide dismutase.
