Fig. 3.

Heat maps of the gene expression in microglia cells exposed to LPS. Selected up regulated (red) and down regulated (blue) genes are listed; genes were selected with ToppCluster based on their significance in the immune response (logP > 4.00) (a) Heat map of 205 differentially expressed (padj < 0.1) up regulated genes (red) in N_L microglia. Interaction network highlights the position of NFKB and JAK3 genes. Protein-protein interaction networks were built with the STRING database on human orthologs and disconnected nodes were not representend. (b) Heat map of 53 differentially expressed down regulated genes in N_L microglia, among selected genes indicated in blue, HMOX1 was strongly differentially expressed (Log₂ = −2.686 and padj = 3.09 × 10−8). In both up and down regulated genes, we observed a different behavior for N_L3 that did not affect our differential analysis. On the right, interaction network shows how HMOX1 and FOS are connected. N_C = Naïve control microglia, N_L = Naïve LPS-exposed microglia (Cao et al., 2015). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)