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APOE effect modification was observed for COMT + BDNF additive effect on EF performance. APOE ε4+ carriers had poorer EF performance with increasing allelic risk in the COMT + BDNF risk panel at age 75 years and borderline 9-year decline. In contrast, the APOE ε4- group was protected from the deleterious effect on EF performance and decline with increasing allelic risk in the COMT + BDNF risk panel.
