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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Gynecol Oncol. 2017 Jan 29;145(1):167–175. doi: 10.1016/j.ygyno.2017.01.022

Figure 6. Proposed model of the TF-FVIIa-PAR-2 axis.

Figure 6

Formation of TF-FVIIa complex (on TF-containing MP) triggers thrombin generation via the extrinsic coagulation pathway and PAR-2 signaling in EOC cells. Local thrombin generation activates PAR-1 on EOC, triggering cellular proliferation. Direct PAR-2 activation by TF-FVIIa results in VEGF-A (and other growth factor) release by EOC cells, promoting ascites formation, angiogenesis and tumor migration/invasion.