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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Exp Eye Res. 2016 Nov 9;154:70–78. doi: 10.1016/j.exer.2016.11.008

Fig. 1. Role of glutathione in lens cataract formation.

Fig. 1

Schematic diagram of the role of glutathione in protection of lens proteins from oxidative damage. GSH can neutralise reactive oxygen species (ROS) directly, and form GSSG as a result. GSH can be regenerated by glutathione reductase (GR) and the coenzyme NADPH. If GSH is depleted, protein mixed disulfides can form (PSSG), leading to protein cross-linking (PSSP), protein aggregation and lens opacification. Adapted from Lou et al (2003).