Table 1.
Early nomenclature | Revised nomenclature | Implication |
---|---|---|
Primary dystonia | Isolated dystonia | “Primary”: not reliable for etiology |
Essential myoclonus | Myoclonus dystonia54 Benign hereditary chorea55 |
“Essential myoclonus” encompassed a syndrome |
Essential palatal tremor |
Isolated palatal tremor including special skills, functional palatal tremor and tics56, 57 |
“Essential” included other recognizable palatal tremors |
Senile gait | Highest-level gait disorder Parkinsonian gait |
“Senile”58 wrongly implied changes due to normal aging |
Senile chorea | Most often late-onset Huntington disease, antiphospholipid antibody syndrome, hypocalcemia, or tardive dyskinesia59 |
“Senile” chorea wrongly suggests it may be due to normal aging |
Idiopathic Parkinson’s disease |
PARK1, 2, 4, 7, 8… Ongoing genetic-molecular phenotyping |
“Idiopathic” becomes an ever narrowing slice of PD, as genetic/molecular etiologies are unveiled |