Figure 5. Effect of estradiol and decreased occlusal loading on bone architecture.
The data represent WT and ERβKO mice under normal load or decreased occlusal loading with either placebo or estradiol treatment. Bone volume fraction (A), trabecular number (B), trabecular thickness (C), and trabecular spacing (D) as determined by microCT are shown. Statistical significance was determined by a two-way ANOVA followed by posthoc analysis with the Bonferonni method with p < 0.05. Exact p values are listed above the bars that denote significance.